Xeglyze™ Lotion is a topical lotion containing an inhibitor of metalloproteinases. These proteinases are important for survival in all stages of the louse lifecycle from egg to adult.
The metalloproteinase inhibitor that is the active agent in Xeglyze™ Lotion is being developed specifically for the treatment of head lice eggs and crawling lice. This active ingredient has undergone extensive testing in both preclinical and clinical studies which has provided support for the ongoing development of Xeglyze™ Lotion.
Young, A.R., Mancuso, N., Bowles, V.M. (1999) Biochemical aspects of egg hatch in endo- and ectoparasites: potential for rational drug design. Int. J. Parasitol. 29, 861-7. Review.
Young, A.R., Mancuso, N., Meeusen, E.N., Bowles, V.M. (2000) Characterisation of proteases involved in egg hatching of the sheep blowfly, Lucilia cuprina. Int. J. Parasitol. 30, 925-32.
Bowles, V.M., Young, A.R., Barker, S.C. (2008) Metalloproteases and egg-hatching in Pediculus humanus, the body (clothes) louse of humans (Phthiraptera: Insecta). Parasitol 135(1):125-130.
Van Hiel, M.B., Breugelmans, B., Pagel, C.N., Williams, A.K., Varan, A.K., Burke, R., Bowles, V.M., Batterham, P. (2012) The Ovicidal, Larvacidal and Adulticidal Properties of 5,5'-Dimethyl-2,2'-Bipyridyl against Drosophila melanogaster. PLoS ONE 7(11): e49961.
Sep 02, 2014 Hatchtech Announces Successful Phase 3 Results
Dec 11, 2013 Hatchtech Receives SPA and Announces Patent Grants